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It also reduces dark eumelanin in favor of the lighter phaeomelanin

The ovary, Malpighian tubules, salivary gland and midguts of the engorged females were dissected in phosphate buffer, frozen with liquid nitrogen and stored at -80 C, and three different developmental periods, including eggs, larvae and adults, were collected for subsequent assays

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Eide et al

HATs such as CREB-binding protein (CBP) or p300 generally promote transcription by enhancing histone acetylation, whereas HDACs such as HDAC1-8 and sirtuins reduce transcription by inhibiting access of transcription factors to DNA (Xia et al., 2020)